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目次

Sphingolipid Biology

Sphingolipid Biology

  • Y.Hirabayashi(編)/ Y.Igarashi(編)/ A.H.Merrill,Jr.(編)
  • Part1:Overview
    • 1-1 Sphingolipids Synthesis,Transport and Cellular Signaling / Yoshio Hirabayashi ; Yasuyuki Igarashi ; Alfred H.Merrill,Jr.
  • Part2:Biosynthesis,Transport of Sphingolipids
    • 2-1 Serine Palmitoyltransferase / Jia Wei ; Tokumbo Yerokun ; Martina Liepelt ; Amin Momin ; Elaine Wang ; Kentaro Hanada ; Alfred H.Merrill,Jr.
    • 2-2 Ceramide Synthase / Irene Pankova‐Kholmyansky ; Anthony H.Futerman
    • 2-3 Dihydroceramide:Sphinganine Δ4‐Desaturase and C4‐Hydroxylase / Akemi Suzuki ; Fumio Omae ; Ayako Enomoto
    • 2-4 Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content / Toshiro Okazaki
    • 2-5 Glucosylceramide and Galactosylceramide Synthase / James A.Shayman
    • 2-6 Synthesis,Metabolism,and Trans‐Bilayer Movement of Long‐Chain Base / Akio Kihara ; Yasuyuki Igarashi
    • 2-7 Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells / Kentaro Hanada ; Miyuki Kawano ; Keigo Kumagai
    • 2-8 Sphingolipid Trafficking / Kouichi Funato ; Howard Riezman
    • 2-9 Current Perspectives on Saccharomyces cerevisiae Sphingolipids / Robert C.Dickson ; Robert L.Lester
  • Part3:Generation and Degradation of Sphingolipid Signaling Molecules
    • 3-1 Generation of Signaling Molecules by De Novo Sphingolipid Synthesis / Kazuyuki Kitatani ; L.Ashley Cowart ; Yusuf A.Hannun
    • 3-2 Overview of Acid and Neutral Sphingomyelinases in Cell Signaling / Youssef Zeidan ; Norma Marchesini ; Yusuf A.Hannun
    • 3-3 Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P‐Mediated Signaling / Makoto Ito ; Motohiro Tani ; Yukihiro Yoshimura
    • 3-4 Activation of Sphingosine Kinase 1 / Michael Maceyka ; Sergio E.Alvarez ; Sheldon Milstien ; Sarah Spiegel
    • 3-5 Ceramide 1‐Phosphate / Susumu Mitsutake ; Tack‐Joong Kim ; Yasuyuki Igarashi
    • 3-6 Sphingosine‐1‐Phosphate Lyase / Julie D.Saba
  • Part4:Membrane Domain and Biological Function
    • 4-1 Close Interrelationship of Sphingomyelinase and Caveolin in Triton X‐100‐Insoluble Membrane Microdomains / Keiko Tamiya‐Koizumi ; Takashi Murate ; Katsumi Tanaka ; Yuji Nishizawa ; Nobuhiro Morone ; Jiro Usukura ; Yoshio Hirabayashi
    • 4-2 Roles of Membrane Domains in the Signaling Pathway for B Cell Survival / Miki Yokoyama ; Tomoko Kimura ; Sachio Tsuchida ; Hiroaki Kaku ; Kiyoshi Takatsu ; Yoshio Hirabayashi ; Masaki Yanagishita
    • 4-3 The Role of Lipid Rafts in Axon Growth and Guidance / Hiroyuki Kamiguchi
    • 4-4 Sphingolipids and Multidrug Resistance of Cancer Cells / Gerrit van Meer ; Maarten Egmond ; David Halter
  • Part5:Membrane Lipid Domain and Human Pathobiology
    • 5-1 A New Pathological Feature of Insulin Resistance and Type 2 Diabetes:Involvement of Ganglioside GM3 and Membrane Microdomains / Jin‐ichi Inokuchi ; Kazuya Kabayama ; Takashige Sato ; Yasuyuki Igarashi
    • 5-2 Neuronal Cell Death in Glycosphingolipidoses / Yaacov Kacher ; Anthony H.Futerman
    • 5-3 Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses / Amit Choudhury ; David L.Marks ; Richard E.Pagano
    • 5-4 Ganglioside and Alzheimer’s Disease / Katsuhiko Yanagisawa
    • 5-5 Modulation of Proteolytic Processing by Glycosphingolipids Generates Amyloid ß‐Peptide / Irfan Y.Tamboli ; Kai Prager ; Esther Barth ; Micheal Heneka ; Konrad Sandhoff ; Jochen Walter
    • 5-6 Hereditary Sensory Neuropathy / Simon J.Myers ; Garth A.Nicholson
    • 5-7 Ceramide,Ceramide Kinase and Vision Defects:A BLIND Spot for LIPIDS / Roser Gonzàlez‐Duarte ; Miquel Tuson ; Gemma Marfany
    • 5-8 Fumonisin Inhibition of Ceramide Synthase:A Possible Risk Factor for Human Neural Tube Defects / Ronald T.Riley ; Kenneth A.Voss ; Marcy Speer ; Victoria L.Stevens ; Janee Gelineau‐van Waes
    • 5-9 Sphingolipids and Cancer / Eva M.Schmelz ; Holly Symolon
  • Part6:S1P Signaling and SIPR
    • 6-1 Sphingosine‐1‐Phosphate and the Regulation of Immune Cell Trafficking / Maria Laura Allende ; Richard L.Proia
    • 6-2 Sphingolipids and Lung Vascular Barrier Regulation / Liliana Moreno ; Steven M.Dudek ; Joe G.N.Garcia
    • 6-3 Signaling Mechanisms for Positive and Negative Regulation of Cell Motility by Sphingosine‐1‐Phosphate Receptors / Yoh Takuwa ; Naotoshi Sugimoto ; Noriko Takuwa ; Yasuyuki Igarashi
    • 6-4 Sphigosine 1‐Phosphate‐Related Metabolism in the Blood Vessel / Yutaka Yatomi ; Shinya Aoki ; Yasuyuki Igarashi
  • Part7:Advanced Technology in Sphingolipid Biology
    • 7-1 Conventional/Conditional Knockout Mice / Ichiro Miyoshi ; Tadashi Okamura ; Noriyuki Kasai ; Tetsuyuki Kitamoto ; Shinichi Ichikawa ; Soh Osuka ; Yoshio Hirabayashi
    • 7-2 Biosynthesis and Function of Drosophila Glycosphingolipids / Ayako Koganeya‐Kohyama ; Yoshio Hirabayashi
    • 7-3 Characterization of Genes Conferring Resistance Against ISP‐1/Myriocin‐Induced Sphingolipid Depletion in Yeast / Hiromu Takematsu ; Yasunori Kozutsumi
    • 7-4 Lysenin:A New Probe for Sphingomyelin / Toshihide Kobayashi ; Akiko Yamaji‐Hasegawa
    • 7-5 Structural Biology of Sphingolipid Synthesis / Hiroko Ikushiro ; Akihiro Okamoto ; Hideyuki Hayashi
    • 7-6 A Computer Visualization Model for the De Novo Sphingolipid Biosynthetic Pathway / Jim Young Hong ; Jeremy C.Allegood ; Samuel Kelly ; Elaine Wang ; Alfred H.Merrill Jr. ; May Dongmei Wang
  • Appendix
    • Ⅰ.Inhibitors of Sphingolipid Biosynthesis / Jin‐ichi Inokuchi
    • Ⅱ.The Genes in Yeast and Mammals / Yasuyuki Igarashi ; Akio Kihara ; Yoshio Hirabayashi
    • Ⅲ.Structure of Glycosphingolipids and Metabolic Pathway / Akemi Suzuki
  • Keyword Index